A082304: PROSPECT LUNG Trial — Comparing Perioperative vs. Adjuvant Systemic Therapy for Resectable Stage II–IIIB NSCLC

Study Overview:
 This Phase III study investigates whether giving systemic therapy before and after surgery (perioperative) improves outcomes compared to the standard approach of post-surgical treatment only (adjuvant) in patients with Stage II–IIIB non-small cell lung cancer (NSCLC).

Key Study Details:

  • Phase & Design: Phase III, randomized

  • Population: Patients with resectable Stage II–IIIB NSCLC

  • Treatment Arms:

    1. Perioperative systemic therapy (before + after surgery)

    2. Adjuvant systemic therapy (after surgery only)

  • Primary Objective: Improve overall survival

  • Why It Matters: Optimizing treatment timing could enhance surgical success, reduce recurrence, and extend survival..

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