NRG-CC014: PREEMPT Trial — Preventative Radiation Therapy vs. Standard Care to Reduce Bone Complications in High-Risk Metastatic Cancer

Study Overview:
 NRG-CC014 evaluates whether giving early preventative radiation therapy can lower the risk of complications like bone fractures, spinal cord compression, and severe pain in patients with metastatic cancer and high-risk bone lesions that are not yet causing symptoms.

Key Study Details:

• Phase & Design: Randomized interventional

• Population: Patients with metastatic cancer and high-risk asymptomatic bone metastases

• Treatment Arms: Preventative radiation therapy vs. standard care (drug therapy or observation)

• Primary Objective: Reduce skeletal-related events and improve mobility

• Why It Matters: Early treatment may prevent painful, disabling complications and improve quality of life.