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NRG-HN009: Head & Neck Cancer Trial — Weekly Low-Dose vs. High-Dose Cisplatin With Radiation for Locoregionally Advanced SCCHN

Study Overview:
This Phase II/III randomized trial compares weekly low-dose cisplatin versus high-dose cisplatin every 3 weeks, both combined with radiation, for patients with locoregionally advanced squamous cell carcinoma of the head and neck (SCCHN). The goal is to balance efficacy and tolerability to improve patient outcomes.

Key Study Details:

  • Phase & Design: Phase II/III, randomized

  • Population: Patients with advanced SCCHN

  • Treatment Arms: Weekly cisplatin vs. every-3-week cisplatin, both with radiation

  • Primary Objective: Compare overall survival and disease control

  • Why It Matters: Could identify a less toxic regimen without compromising effectiveness

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