GU013: High Five Trial — Evaluating 5-Fraction SBRT vs. Conventional Radiation for High-Risk Prostate Cancer

Study Overview:
This Phase III trial compares three radiation strategies for men with high-risk prostate adenocarcinoma:

• Ultrahypofractionated SBRT (5 sessions)

• Moderate hypofractionation

• Conventional fractionation

The goal is to determine whether fewer, higher-dose treatments can achieve the same or better cancer control while improving convenience and quality of life.

Key Study Details:

• Phase & Design: Phase III, randomized

• Population: Men with high-risk localized prostate adenocarcinoma

• Treatment Arms: SBRT vs. moderate hypofractionation vs. conventional fractionation

• Primary Objective: Compare metastasis-free survival

• Why It Matters: Shorter treatment schedules reduce burden, cost, and hospital visits without compromising effectiveness.